Product Name：MxSafe Plus（Security nucleic acid dye）

Catalog Number: Mx017

HeLa cells were incubated at 37 ^oC with 1X of SYBR Green I, MxSafe and MxSafe Plus,respectively. Images were taken 

following incubation for 5 min (panel A) and 30 min (panel B), respectively.SYBR Green I entered into cells rapidly as ev

-ident from the bright green nuclear staining. However, MxSafe and MxSafe Plus were unable to cross cell membranes 

as shown by the lack of any fluorescence staining.

MxSafe Plus  is an ultra sensitive, extremely stable and environmentally safe fluorescent nucleic acid dye designed to replace 

the highly toxic ethidium bromide (EB) for staining dsDNA, ssDNA or RNA in agarose gels or polyacrylamide gels. MxSafe Plus

is far more sensitivethan EB without requiring a destaining step. MxSafe  Plus and EB have virtually the same spectra, so you 

can directly replace EB with MxSafe Plus  without changing your existing imaging system.

MxSafe Plus is a very stable dye. Store 10,000X solution and dilute solutions of MxSafe Plus  at room temperature, 

protected from light. Dye  precipitation  may  occur  at  lower  temperatures, resulting  in  lower     signal   or   the  

appearance  of precipitate on the surface of the gel. If this occurs, heat the solution  to 45-50^oC  for two   minutes 

and vortex. MxSafe Plus is stable for at least one year from the date it is received.